Developmental expression of Ki-67 antigen and proliferating cell nuclear antigen in macaque placentas
نویسندگان
چکیده
منابع مشابه
Proliferating cell nuclear antigen expression in childhood acute leukemia.
Proliferating cell nuclear antigen (PCNA) is a 36-Kd nuclear protein, identified as the auxiliary protein of DNA polymerase delta, that is upregulated in activated proliferating cells from a variety of tissues and species, including human lymphocytes. We have examined by two-dimensional polyacrylamide gel electrophoresis the expression of PCNA in various subtypes of childhood acute leukemia and...
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AIMS To correlate the expression of proliferating cell nuclear antigen (PCNA) with various clinicopathological features of papillary thyroid carcinoma. METHODS Sections from 131 formalin fixed, paraffin wax embedded papillary thyroid carcinomas were stained with a monoclonal antibody (PC10) directed against PCNA using the avidin-biotin immunoperoxidase (ABC) method. PCNA immunoreactivity was ...
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BACKGROUND/AIM Prostatic intraepithelial high grade neoplasia (PINHG) is accepted as preneoplastic lesion in prostatic carcinoma. One of the fundamental events in early oncogenesis is the disruption of proliferative activity. One of the numerous regulatory proteins is Ki-67 expressed in all proliferating cells. Index Ki-67 is considered to have prognostic significance. The aim of the study was ...
متن کاملExpression of nuclear antigen Ki-67 in prostate cancer needle biopsy and radical prostatectomy specimens.
A good biomarker is defined as any test (molecular, morphometric, etc.) that adds independent information to standard prognostic indicators (e.g., pathologic evaluation or clinical stage), that can be reliably reproduced in the laboratory setting, and that aids in choosing treatment options (1). The primary objective of this study was to determine if the proliferation marker Ki-67, a nuclear an...
متن کاملAntisense Proliferating Cell Nuclear Antigen Oligonucleotides
We have used antisense phosphorothioate oligonucleotides to define the role played by proliferating cell nuclear antigen (PCNA) in neointimal accumulation of smooth muscle cells in a rat carotid artery injury model. The short-term extraluminal delivery of 250 nmol of antisense oligonucleotides, but not control oligonucleotides, immediately after arterial injury produces a 77% suppression of PCN...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 1994
ISSN: 1058-8388
DOI: 10.1002/aja.1002010404